Wall Street climbs as China data puts S&P back at five-year high

NEW YORK (Reuters) - Stocks rose on Thursday and the S&P 500 ended at a fresh five-year high as stronger-than-expected exports from China spurred optimism about global growth prospects.

Buying accelerated late in the day after the S&P 500 broke through technical resistance at 1,466.47, which was the market's closing level last Friday and the highest level since December 2007.

"Historically, January is a positive month for the market and you're seeing that play out," said Michael Sheldon, chief market strategist at RDM Financial in Westport, Connecticut.

Financial and energy stocks were the day's top gainers. The financial sector index <.gspf> rose 1.4 percent and the energy sector <.gspe> was up 1 percent.

Analysts cited economic data out of China as the day's catalyst, which showed the country's export growth rebounded sharply to a seven-month high in December, a strong finish to the year after seven straight quarters of slowdown.

"It is being interpreted positively that they've stopped the downturn (in growth)," said Kurt Brunner, portfolio manager at Swarthmore Group in Philadelphia.

"If they continue to produce good growth, that's going to be supportive of our global manufacturers."

Wall Street's fear gauge, the CBOE Volatility Index <.vix> suggested markets were relatively calm. The VIX was down 2.3 percent at 13.49.

At Thursday's close, the S&P sits about 6 percent below its all-time closing high of 1,565.15, hit in October 2007.

The Dow Jones industrial average <.dji> gained 80.71 points, or 0.60 percent, to 13,471.22. The Standard & Poor's 500 Index <.spx> rose 11.10 points, or 0.76 percent, to 1,472.12. The Nasdaq Composite Index <.ixic> added 15.95 points, or 0.51 percent, to 3,121.76.

Thursday's session had earlier included a dip that traders said was triggered by a trade in the options market that prompted a large amount of S&P futures to hit the market at the same time. That sent the S&P 500 index down rapidly but those losses were reversed through the afternoon.

Financials benefited from events this week that added clarity to mortgage rules and banks' potential exposure to the housing market.

The U.S. government's consumer finance watchdog announced mortgage rules on Thursday that will force banks to use new criteria to determine whether a borrower can repay a home loan.

Earlier this week, several big mortgage lenders reached a deal with regulators to end a review of foreclosures mandated by the government.

"It's a resolution. It's not hanging over their heads," said Brunner.

Bank of America gained 3.1 percent to $11.78, while Morgan Stanley was up 3.7 percent at $20.34, one day after sources said the bank plans to cut jobs.

Shares of upscale jeweler Tiffany dropped 4.5 percent to $60.40 after it said sales were flat during the holidays.

Herbalife Ltd stepped up its defense against activist investor Bill Ackman, stressing it was a legitimate company with a mission to improve nutrition and help public health. The stock ended down 1.8 percent at $39.24 after a volatile day.

After the closing bell, American Express said it would cut about 5,400 jobs, and take about $600 million in after-tax charges in the fourth quarter. The stock added 0.7 percent to $61.20 in after-hours trade.

Volume was above the 2012 average of 6.42 billion shares traded a day, with roughly 6.77 billion shares changing hands on the New York Stock Exchange, the Nasdaq and the NYSE MKT.

Advancers outnumbered decliners on the NYSE by 1,916 to 1,039, while advancers also outpaced decliners on the Nasdaq by 1,439 to 1,036.

(Editing by Nick Zieminski)

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The Lede Blog: Winter Brings Misery to Syria Refugees

For Syrian refugees in the Zaatari refugee camp in Jordan, winter has brought bitter new hardship and at least one death.

More than 50,000 people are estimated to live in the Zaatari camp, roughly one-third of the nearly 150,000 Syrians who have sought refuge in Jordan from the 22-month-long conflict gripping their country. As my colleagues Rick Gladstone and Nick Cumming-Bruce have reported, wind and rainy weather this week wrecked scores of refugee dwellings in Zaatari, where many tents flooded or collapsed. People were left shivering in the cold, and outrage soon boiled over in an angry riot that injured 11 people, more than half of them aid workers from the charity group Save the Children. It was the latest in at least four violent episodes in recent weeks between refugees, aid workers and the police.

Video of the Zaatari camp on Monday, posted online by Syrian activists, showed an area almost as large as a football field covered in shallow, muddy water. Inside a soaked tent, a young boy told the cameraman that he and his family, including his injured father, “went to a neighbor’s tent because of the water.”

Tents in the Zaatari refugee camp were flooded with shallow, muddy water on Monday.

The suffering in Zaatari was given a human face on Wednesday when an activist uploaded a moving video interview with a refugee named Khaled al-Hariri, an amputee who described the difficulty of getting proper medical care in the camp. According to the activist, Abushakraa Horanee, Mr. Hariri died on Tuesday night before the video was uploaded to Facebook and then copied to a Syrian activist YouTube channel. Mr. Horanee, the filmmaker, called Mr. Hariri “the martyr of negligence and cold.”

Video of Khaled al-Hariri, a Syrian refugee in Jordan, accusing camp doctors of negligence.

In the video, Mr. Hariri, who lost a leg in Syria before fleeing to Jordan, said he suffered from a range of respiratory problems that went untreated by camp doctors. Mr. Hariri broke down crying as he explained his health problems and alleged negligence and poor treatment on the part of doctors in the camp, which is run by the United Nations. “I don’t even want my health to improve,” he said. “I want my brothers’ health, the people all around me, to improve.”

Describing his ill health, Mr. Hariri said: “I have hoarseness, chest pain and mucus. With my leg pain. Here my leg, all of it, is inflamed. My chest also, my chest is inflamed.”

When asked if camp doctors provided a diagnosis, Mr. Hariri responded:

Diagnosed? No one diagnosed me. I stayed here for three months and no doctor gave me a proper drug, no doctor told me, ‘here is a drug for that’, no doctor gave me anything. I just want something that will give me some relief. I just want something to give me some relief, that’s all. Painkillers. They didn’t give me that. I don’t know, what can I do?

Asked how doctors in the camp hospital responded to his visit, he said:

Their response? I would go at night from here to the emergency room and call on them and tell them, ‘My brother, for God’s sake….’ I would tell the ambulance driver: ‘My brother, for God’s sake, I swear I can’t breathe. I need oxygen, I need oxygen.’ So the ambulance would arrive and they wouldn’t even pick me up themselves. My brother, the broken one, would pick me and my uncle. They would pick me up and put me in the ambulance. Is that O.K.?

I would go and sit there. I’d be wearing this track suit while it’s cold outside. I would ask, where is the doctor for him to put me in a bed? And the doctor would say: ‘There is no bed. You’re going to have to wait a bit for the patient to leave.’ ‘Doctor, I swear I’m very tired. At least give me oxygen, I want to breathe. I can’t breathe.’ I could not breathe at all.

United Nations officials said that most dwellings in the camp withstood the recent rainfall and attributed tensions in Zaatari to a range of factors, including fear of worsening weather and a surge of as many as 9,000 new residents in the last week. On Twitter, Unicef, the United Nations children’s agency, said the organization was fully focused on improving conditions in the camp.

We’re working around clock to tackle flooding in #Zaatari camp and ensure all refugees have shelter & sanitation http://t.co/8SYmLRUi #Syria

— UNICEF (@UNICEF) 10 Jan 13

---

This post has been revised to reflect the following correction:

Correction: January 11, 2013

A caption with a picture in an earlier version of this post incorrectly said on which day a Syrian, Khaled al-Hariri, died in a refugee camp in Jordan. As the post said, it was Tuesday, not Wednesday.

This post has been revised to reflect the following correction:

Correction: January 11, 2013

A caption with a video in an earlier version of this post misspelled the surname of a Syrian refugee. He is Khaled al-Hariri, not Khaled al-Zubi.

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A Tale of 2 Strategies: The Twitter Genius of Chuck Grassley and Cory Booker

If you’re on Twitter and not following Sen. Chuck Grassley, you’re not using Twitter correctly.

The Iowa Republican is known for his colorful and personal Twitter feed. Take a gander: He personally tweets about everything from the History Channel to “Obamacare” to an incident in which he hit a deer with his car  (“assume dead”). Grassley’s tweets take us along for a ride, one that’s often riddled with spelling errors (which he has said is due to his distaste for typing and the iPhone’s auto-correct function).

Pres/Cong need 2work on Wash spending prob. No time 2waste b/4 Mar. Pres promised tax hike is done. Now he needs 2keep promise 4 less spend

— ChuckGrassley (@ChuckGrassley) January 4, 2013

Rained inIowa this weekend. Still 8 inches shortIowa still still listed dangerous drought pray For rain

— ChuckGrassley (@ChuckGrassley) December 17, 2012

Fred and I hit a deer on hiway 136 south of Dyersville. After I pulled fender rubbing on tire we continued to farm. Assume deer dead

— ChuckGrassley (@ChuckGrassley) October 26, 2012

Contrast Grassley’s tweets to another lawmaker known for his active and personal feed: Newark, N.J., Mayor Cory Booker. On Twitter, he’s part mayor, part celebrity. Booker tweets about city services and was widely praised for how he utilized the platform in the aftermath of superstorm Sandy to connect directly with residents. But then he’ll retweet someone who says she’s going to get a Cory Booker quote tattoo or someone who has a “political crush” on him. Sometimes, Booker tweets like a Kardashian.

Think so, call 9737334311. My people will tell u RT @hennybottle: Is the number to get downed wires removed same for all of essex county?

— Cory Booker (@CoryBooker) January 8, 2013

“Hey, Never Met U, Your tweet’s Crazy, I’ll DM My Number, So Call Me Maybe?” MT @ann_ralston: I have a non-sexual, political crush on you!

— Cory Booker (@CoryBooker) January 8, 2013

Wow. An honor I never quite imagined RT @rachelanncohen: deliberating between several Cory Booker quotes for my next tattoo.

— Cory Booker (@CoryBooker) January 8, 2013

I love you too! RT @alwoldegorgeous: I can actually say I am in love with @kimkardashian#girlcrush

— Kim Kardashian (@KimKardashian) December 12, 2012

Obviously, Booker is savvier with Twitter than Grassley, and he’s utilized the platform effectively, as he vies for statewide office. Booker’s a PR genius with social media. Grassley’s himself–typos, rants, and all. So while Booker probably doesn’t need to take Twitter lessons from the six-term senator, there’s something decidedly old school and earnest that’s kind of appealing about Grassley’s feed, something that would be nice to see in Booker’s feed, too.

Welcome to Twitter Pope Benedict. U will find it useful and interesting

— ChuckGrassley (@ChuckGrassley) December 3, 2012

CORRECTION: Grassley has served in the Senate for six terms.  An earlier version of the story incorrectly listed his tenure.

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Audrey Hepburn: Remembering the Private Legend

By Elizabeth McNeil

01/10/2013 at 07:35 PM EST

Audrey Hepburn with her son, Luca Dotti, in 1985

Audrey Hepburn Childrens Fund

She captivated the world with her doe-eyed beauty, but behind the Givenchy glamour, there was an Audrey Hepburn few people knew.

She thought her nose too big, her feet too large and her neck too long. She loved to shop for groceries (but not clothes), didn't wear makeup at home, never went to the gym and enjoyed two fingers of Scotch every night. 

"She was not this ethereal creature," says Robert Wolders, 76, the Dutch actor who was her companion for the last 13 years of her life. "She was an earthy woman with a ribald sense of humor."

What Hepburn had, adds Wolders, "was more than beauty. It was this extraordinary mystique."

Hepburn left Hollywood at age 34 at the height of her fame, moving into a 1732 farmhouse in Tolochenaz, a small Swiss village, where she found happiness raising two sons and purpose in her charity work for UNICEF. 

Two decades after her death from abdominal cancer at 63 on Jan. 20, 1993, her children and her last love remember the Audrey they adored. 

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Flu season strikes early and, in some places, hard

NEW YORK (AP) — From the Rocky Mountains to New England, hospitals are swamped with people with flu symptoms. Some medical centers are turning away visitors or making them wear face masks, and one Pennsylvania hospital set up a tent outside its ER to deal with the feverish patients.

Flu season in the U.S. has struck early and, in many places, hard.

While flu normally doesn't blanket the country until late January or February, it is already widespread in more than 40 states, with about 30 of them reporting some major hot spots. On Thursday, health officials blamed the flu for the deaths of 20 children so far.

Whether this will be considered a bad season by the time it has run its course in the spring remains to be seen.

"Those of us with gray hair have seen worse," said Dr. William Schaffner, a flu expert at Vanderbilt University in Nashville.

The evidence so far points to a moderate season, Schaffner and others say. It looks bad in part because last year was unusually mild and because the main strain of influenza circulating this year tends to make people sicker and really lay them low.

David Smythe of New York City saw it happen to his 50-year-old girlfriend, who has been knocked out for about two weeks. "She's been in bed. She can't even get up," he said.

Also, the flu's early arrival coincided with spikes in a variety of other viruses, including a childhood malady that mimics flu and a new norovirus that causes vomiting and diarrhea, or what is commonly known as "stomach flu." So what people are calling the flu may, in fact, be something else.

"There may be more of an overlap than we normally see," said Dr. Joseph Bresee, who tracks the flu for the Centers for Disease Control and Prevention.

Most people don't undergo lab tests to confirm flu, and the symptoms are so similar that it can be hard to distinguish flu from other viruses, or even a cold. Over the holidays, 250 people were sickened at a Mormon missionary training center in Utah, but the culprit turned out to be a norovirus, not the flu.

Flu is a major contributor, though, to what's going on.

"I'd say 75 percent," said Dr. Dan Surdam, head of the emergency department at Cheyenne Regional Medical Center, Wyoming's largest hospital. The 17-bed emergency room saw its busiest day ever last week, with 166 visitors.

The early onslaught has resulted in a spike in hospitalizations. To deal with the influx and protect other patients from getting sick, hospitals are restricting visits from children, requiring family members to wear masks and banning anyone with flu symptoms from maternity wards.

One hospital in Allentown, Pa., set up a tent this week for a steady stream of patients with flu symptoms. But so far "what we're seeing is a typical flu season," said Terry Burger, director of infection control and prevention for the hospital, Lehigh Valley Hospital-Cedar Crest.

On Wednesday, Boston declared a public health emergency, with the city's hospitals counting about 1,500 emergency room visits since December by people with flu-like symptoms.

All the flu activity has led some to question whether this year's flu shot is working. While health officials are still analyzing the vaccine, early indications are that it's about 60 percent effective, which is in line with what's been seen in other years.

The vaccine is reformulated each year, based on experts' best guess of which strains of the virus will predominate. This year's vaccine is well-matched to what's going around. The government estimates that between a third and half of Americans have gotten the vaccine.

In New York City, 57-year-old Judith Quinones skipped getting a flu shot this season and suffered her worst case of flu-like illness in years. She was laid up for nearly a month with fever and body aches. "I just couldn't function," she said.

But her daughter got the vaccine. "And she got sick twice," Quinones said.

Europe is also suffering an early flu season, though a milder strain predominates there. Flu reports are up, too, in China, Japan, the West Bank, the Gaza Strip, Algeria and the Republic of Congo. Britain has seen a surge in cases of norovirus.

On average, about 24,000 Americans die each flu season, according to the CDC. That's an estimate — the agency does not keep a running tally of adult flu deaths each year, only for children. Some state health departments do keep count, and they've reported dozens of flu deaths so far.

Flu usually peaks in midwinter. Symptoms can include fever, cough, runny nose, head and body aches and fatigue. Some people also suffer vomiting and diarrhea, and some develop pneumonia or other severe complications.

Most people with flu have a mild illness and can help themselves and protect others by staying home and resting. But people with severe symptoms should see a doctor. They may be given antiviral drugs or other medications to ease symptoms.

Flu vaccinations are recommended for everyone 6 months or older. Of the 20 children killed by the flu this season, only two were fully vaccinated.

___

AP Medical Writer Maria Cheng in London contributed to this report.

___

Online:

CDC flu: http://www.cdc.gov/flu/index.htm

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Wall Street rises after Alcoa reports earnings

NEW YORK (Reuters) - Stocks rose on Wednesday, rebounding from two days of losses, as investors turned their focus to the first prominent results of the earnings season.

Stocks had retreated at the start of the week from the S&P 500's highest point in five years, hit last Friday, on worries about possible earnings weakness.

Shares of Alcoa Inc were down 0.5 percent to $9.08 after early gains, following the company's earnings release after the bell on Tuesday. The largest U.S. aluminum producer said it expects global demand for aluminum to grow in 2013.

Herbalife Ltd stock rose 4.2 percent to $39.95 in its most active day of trading in the company's history after hedge fund manager Dan Loeb took a large stake in the nutritional supplements seller. Prominent short-seller Bill Ackman had previously accused the company of being a "pyramid scheme," which Herbalife has denied.

Traders have been cautious as the current quarter shaped up like the previous one, with companies recently lowering expectations, said James Dailey, portfolio manager of Team Asset Strategy Fund in Harrisburg, Pennsylvania. Lower expectations leave room for companies to surprise investors even if their results are not particularly strong.

"The big question and focus is on revenue, and Alcoa had better-than-expected revenue," which calmed the market a little, Dailey said.

Overall, corporate profits were expected to beat the previous quarter's meager 0.1 percent rise. Both earnings and revenues in the fourth quarter are expected to have grown by 1.9 percent, according to Thomson Reuters data.

The Dow Jones industrial average <.dji> gained 61.66 points, or 0.46 percent, to 13,390.51. The Standard & Poor's 500 Index <.spx> rose 3.87 points, or 0.27 percent, to 1,461.02. The Nasdaq Composite Index <.ixic> gained 14.00 points, or 0.45 percent, to 3,105.81.

Facebook Inc shares rose above $30 for the first time since July 2012, trading up 5.3 percent at $30.59. Facebook, which has been tight-lipped about its plans after its botched IPO in May, invited the media to its headquarters next week.

Clearwire Corp shares jumped 7.2 percent to $3.13 after Dish Network bid $2.28 billion for the company, beating out a previous Sprint offer and setting the stage for a takeover battle for the wireless service provider that owns crucial mobile spectrum.

Apollo Group Inc slid after heavier early losses, a day after it reported lower student sign-ups for the third straight quarter and cut its operating profit outlook for 2013. Apollo's shares were last off 7.8 percent at $19.32.

Volume was below the 2012 average of 6.42 billion shares traded per day, as 6.10 billion were traded on the New York Stock Exchange, NYSE MKT and Nasdaq.

Advancing stocks outnumbered declining ones on the NYSE by 2,014 to 963, while on the Nasdaq advancers beat decliners 1,603 to 859.

(Reporting by Gabriel Debenedetti; additional reporting by Angela Moon; Editing by Nick Zieminski)

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Venezuelan Court: Chávez Swearing-In Can Be Postponed

CARACAS, Venezuela (AP) — Venezuela's Supreme Court chief on Wednesday endorsed putting off President Hugo Chavez's inauguration, siding with the government in a heated dispute with the opposition while the ailing leader struggles with complications a month after cancer surgery in Cuba.

Supreme Court President Luisa Estella Morales made the statement after the opposition urged the top court to rule that the government was violating the constitution by delaying the swearing-in for a new term, which had been scheduled for Thursday. Lawmakers voted Tuesday to delay the ceremony, allowing Chavez to take the oath of office at an unspecified later date before the Supreme Court.

Morales also said the Supreme Court hasn't considered appointing a panel of doctors, as opposition politicians have demanded, to evaluate whether Chavez is fit to remain in office after remaining out of public view since before his Dec. 11 operation.

Her announcement seemed to pre-empt any opposition attempt to challenge the postponed inauguration. She announced the decision in response to a case brought by a single lawyer, and said the inauguration can be performed before the Supreme Court, at a time and place to be determined.

"We know it's necessary, and undoubtedly the inauguration is going to be carried out, but at this time we can't anticipate when," Morales told reporters at a news conference.

Opposition leader Henrique Capriles condemned the Supreme Court's endorsement of delaying the inauguration. "Institutions should not respond to the interests of a government," he said at a news conference.

The case that prompted the decision was brought not by the opposition but by a private lawyer, Marelys D'Arpino, a columnist for the pro-Chavez newspaper Vea. D'Arpino told The Associated Press that she decided to file the case last month because "it was necessary to straighten out" the matter before the court.

The constitutional debate takes place against a backdrop of complaints that the government isn't giving complete information about the condition of Chavez, who hasn't spoken publicly since his fourth cancer-related surgery in Cuba four weeks ago.

"It's very evident that he isn't governing, and what they want us to believe is that he's governing, and they're lying," opposition leader Ramon Guillermo Aveledo told the television channel Globovision. He insisted that the National Assembly president should take over temporarily as interim leader and that the Supreme Court should appoint a panel of doctors to determine Chavez's condition.

It was unclear how the opposition would respond to Morales' statement.

Venezuela's constitution says the oath of office should be taken before lawmakers in the National Assembly on Jan. 10. But the charter adds that if he is unable to be sworn in by the National Assembly, the president may take the oath before the Supreme Court, without explicitly stating a date.

Opponents maintain that even if the oath is taken before the Supreme Court, it should be on Jan. 10.

The opposition has argued that the only legal way to postpone the ceremony is for congress to approve a "temporary absence" for the president, leaving the head of the National Assembly as interim president for 90 days, a period that could be extended for an additional 90 days.

But Morales said that as of now, "there is not even a temporary absence."

Vice President Nicolas Maduro broke the news that Chavez would not be able to attend the scheduled inauguration in a letter to National Assembly President Diosdado Cabello, which he announced he had received on Tuesday.

On Wednesday, Maduro hosted a meeting with leaders from 19 Latin American and Caribbean nations. He planned to discuss issues related to Petrocaribe, a pact that has boosted Venezuela's influence in the region. The South American nation created Petrocaribe in 2005 to sell fuel to member countries at preferential terms.

Visiting leaders and foreign ministers are expected to attend an event Thursday to show their support for Chavez.

Chavez said before his operation that if he were unable to continue as president, Maduro should take his place and run in an election to replace him. Speculation that his illness might be entering its final stages grew on Tuesday when the proposal for a postponement came in a letter signed by Maduro, not Chavez.

The government said earlier this week that Chavez was in a "stable situation" receiving treatment due to a severe respiratory infection. The government has said he is coping with "respiratory deficiency," but hasn't said how severe it is.

The stances of the government and the Supreme Court have been criticized by legal scholars such as Vicente Gonzalez de la Vega, a law professor at Central University of Venezuela, who said the Supreme Court has effectively consummated a sort of "coup d'etat."

"How can it say that the president isn't absent and he's in his duties when he can't even sign a letter?" Gonzalez told the AP.

Francisco Madrid, a businessman and opposition supporter, called the Supreme Court's decision "shameful."

"It's proof that all branches of the state respond to the government's interests," Madrid said while walking in downtown Caracas. He also complained that while the government is focused on such issues, there are shortages of foods such as sugar, chicken and flour.

___

Associated Press writers Vivian Sequera and Christopher Toothaker contributed to this report.

___

AP Interactive: http://hosted.ap.org/interactives/2012/venezuela/

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Go Ahead, Keep Being Mean to Celebrities on Twitter

We realize there’s only so much time one can spend in a day watching new trailers, viral video clips, and shaky cell phone footage of people arguing on live television. This is why every day The Atlantic Wire highlights the videos that truly earn your five minutes (or less) of attention. Today:  

RELATED: The Honey Boo Boo Nature Special; Everyone’s Favorite Sleepwalking Mom

We usually don’t condone being an impolite jerk to anyone, especially on social media. But we kind of make an exception because, well, if everyone was nice to everyone all of a sudden, we’d run out of fun Jimmy Kimmel segments where celebrities read their tweets:

RELATED: Ai Weiwei’s ‘Gangnam Style’ Isn’t Bad

RELATED: So Which Boyfriend Is Taylor Swift Singing About Now?

Oh man, this giant squid is like the most famous sea creature celebrity of the moment. And yes, it’s way freakier in motion:

RELATED: Katie Holmes Goes Bust on Broadway

RELATED: Justin Bieber is Coming to Town

So fine, this is sort of bending the rules per se because this isn’t really a video-video. It’s the Game of Thrones introduction with beatboxing by the Stark children. 

And finally, here is one minute of a man singing all the songs involving the word “baby.” And in case you were wondering, yes, Justin Bieber is officially in the Baby Pantheon of Music. 

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Adele Plans to Attend the Golden Globe Awards

01/09/2013 at 07:10 PM EST

Adele is about to emerge!

The Grammy-winning vocalist, 24 – who is nominated for a Golden Globe for her James Bond theme "Skyfall" – will attend the awards show in L.A. on Sunday, PEOPLE has learned.

This will be the first public appearance for the star since giving birth to a son last October.

Another source previously told PEOPLE that Adele and her boyfriend Simon Konecki were "totally laying low and nesting."

Although the very private singer has kept a low profile, her pal comedian Alan Carr recently told The Sun, "I have seen Adele's baby and he's such a cutie. She's doing great, she's glowing."

Now the world is about to see the glowing new mom, too.

The 70th Golden Globe Awards will air live on Sunday, Jan. 13, 2013, on NBC at 8 p.m. ET (5 p.m. PT) from the Beverly Hilton Hotel.

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Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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